Counsel patients regarding the potential risk for MTC with the use of Mounjaro and inform them of symptoms of thyroid tumors (e.g., a mass in the neck, dysphagia, dyspnea, persistent hoarseness). Mounjaro is contraindicated in patients with a personal or family history of MTC or in patients with Multiple Endocrine Neoplasia syndrome type 2 (MEN 2). It is unknown whether Mounjaro causes thyroid C-cell tumors, including medullary thyroid carcinoma (MTC), in humans as human relevance of tirzepatide-induced rodent thyroid C-cell tumors has not been determined. In both male and female rats, tirzepatide causes dose-dependent and treatment-duration-dependent thyroid C-cell tumors at clinically relevant exposures.

Side effects may vary and should be evaluated by the healthcare provider for appropriate management. If more than 4 days have passed, skip the missed dose, and administer the next dose on the regularly scheduled day If a dose is missed, instruct patients to administer as soon as possible within 4 days after the missed dose. Recommend to female patients using oral hormonal birth control to switch to a non-oral birth control method or add a barrier method of birth control for 4 weeks after initiation and for 4 weeks after each dose escalation 3 Mounjaro delays stomach emptying, so it may make birth control pills less effective.

Try eating bland foods like toast, crackers, or rice.

Eat smaller meals–try splitting your 3 daily meals into 4 or more smaller ones.Patients may experience nausea, diarrhea, or vomiting. Set expectations that Mounjaro may cause some side effects:ĭiscuss the Boxed Warning and other warnings/precautions as appropriate for your patient Consider having the patient administer the first dose in the office.Allow the patient to practice the injection using the demonstration device.Advise the patient to read the Instructions for Use 2.Remind patients that Mounjaro is taken once weekly and comes in a single-dose pen with a no-see needle 1.

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